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Eczema drug effective against severe asthma
Science Daily Two new studies of patients with difficult-to-control asthma show that the eczema drug dupilumab alleviates asthma symptoms and improves patients' ability to breathe better than standard therapies. Dupilumab, an injectable anti-inflammatory drug, was … Eczema drug may help asthma sufferers Eczema drug effective against severe asthma – Medical Xpress Eczema jab could offer new hope to millions with asthma – stopping … |
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Vitamin B against Memory Loss and for Healthy Body
According to a study carried out by British researchers on patients related to Alzheimer, taking high doses of Vitamin B in 2 years, the official results has just unveiled that vitamin B can prevent memory loss and even support healthy body. More specifically, the tablets used for researched people, “TrioBe Plus”, contain the high amount of Vitamin and are not available commercially. After the study, the revealed results have proven that Vitamin B can play an essential role in the prevention of memory loss and other brain problems.
Proper digestion
Vitamin B Complex is considered as a vital nutrition for proper digestive function, production of hydrochloric acid and supports in the breakdown of proteins, fats and carbohydrates. In addition, Vitamin B1, B2, B3 and B6 are also of great importance to digestion. Moreover, lack of vitamin B can result in the dysfunctional digestion and insufficient essential nutrients.
Nutritionists suggest taking Vitamin B as a Complex in daily life
The symptom of dysfunctional digestion
Healthy nervous system
Vitamin B Complex is also good for the proper functioning of the nervous system. As a result, the lack of any of the B complex vitamins will cause anxiety, stress, along with depression.
Depression can be started due to the lack of vitamin B
Vitamin B Complex contributes to the good nervous system
Energy production of the body
Vitamin B1 acts as a necessary part of helping convert the carbohydrates eaten into glucose. Vitamin B2, B3, B5, B6 and Biotin are also vital at the cellular level to effectively transfer glucose to energy. One more thing, the shortage of any of above vitamins may lead to the reduced energy production, lethargy, as well as fatigue.
Vitamin B which can be found in lots of fruits and food in the market helps reduce stress and enhance a healthy life
Healthy hair, skin and nails
The skin, hair and nail continuously develop, and the body requires Vitamin B Complex to assure the health of such above growing cells. Consequently, the inadequacy are able to be blamed for such problems as dry skin, dermatitis, wrinkles, rashes, acne, hair loss, along with weak nails.
Biotin can help support healthy hair, skin and nails
Wrinkles are a by-product of the aging process
Related links:
Vitamin B
VitaminB -12 – Cobalamin
VitaminB Complex Deficiency
Louis Brown lives in California, where he enjoys writing articles on a variety of subjects, especially lifestyle. By trade, he is a user interface designer.
Related Atopic Dermatitis Articles
GLUTEN FREE PRESCRIPTIONS – Action Against Allergy
AAA support for coeliacs
Action Against Allergy is giving its support to the campaign being co-ordinated by Coeliac UK to persuade the NHS to seek an alternative to their proposed withdrawal of prescriptions for the gluten free foods needed by people with coeliac disease.
AAA trustee Michelle Berriedale-Johnson writes:
“We believe that removing access to prescription gluten free food may seriously put at risk the future health of the most vulnerable of the coeliac population.
“In the context of the NHS’ current financial crisis, this may also be a false economy. In the longer term, treating vulnerable coeliacs who have been unable to access gluten free foods may cost a great deal more than providing them with prescription foods now.”
Read the rest of the article on the AAA website here
Introducing Action Against Allergy – our latest charity forum partnership
talkhealth are excited to announce that we are now hosting the forums for the charity ‘Action Against Allergy’. Log on to the AAA forums to join the general discussion, view charity news and individual to talkhealth we are especially delighted to announce a forum designed for those living with allergies aged 60 +, the AAAllergy 60 + forum
The Action Against Allergy forums are all now open and we look forward to welcoming you to the conversation.
Action Against Allergy were founded in 1978 and have since offered help, support and advice to those who’s lives are affected by allergies.
Unique to Action Against Allergy is their ‘Find a Doctor’ service which will supply you with the names and contact details of any clinics, appropriate NHS and private specialists dealing with allergy-related illness in your area or, if there are none locally, those which are nearest to you – visit here for more information.
together we can #talkhealth
Skin Defences against Staph Bacteria – Q&A with Dr Donald Davidson
I came across this study “IL-1 beta-induced protection of keratinocytes against Staphylococcus aureus-secreted proteases is mediated by human beta defensin 21” where the researchers studied how the skin protected itself against staphylococcus aureus (“staph bacteria”). This research is important because staph bacteria is known to colonize atopic dermatitis skin, and in doing so, have resulted in worsened control of atopic dermatitis. (Note to readers: Due to many types of eczema, it is recommended to use atopic dermatitis to avoid confusion with other types of eczema like contact dermatitis).
I’m privileged to interview the lead researcher for the study, Dr Donald J Davidson MBChB PhD. Dr Davidson is the MRC Senior Research Fellow and University of Edinburgh Senior Lecturer. The Davidson Group within the MRC Centre for Inflammation Research focuses on understanding the physiological importance of cationic host defence peptides (CHDP) to host defences against bacterial and viral infections. Dr Davidson is a medical graduate of the University of Edinburgh who chose to pursue a scientific research career. He completed a PhD at the MRC Human Genetics Unit, studying the pathogenesis of cystic fibrosis lung disease, then was awarded a Wellcome Trust Travelling Research Fellowship to undertake post-doctoral training in innate immunity research at the University of British Columbia, Vancouver. You can read more of his research interests here.
MarcieMom: Thank you Dr Davidson for taking the time to help with the questions. The questions will be based on the study, but more focused on its practical implications.
Staphylococcus Aureus
Staphylococcus aureus is a resilient bacteria found on the skin that can survive in dry condition and on dry skin with little oxygen. It tends to involve areas that are warm and moist especially such as skin near mucous membranes such as the nose, mouth, genitals and anal area. It is found in less than 30% of healthy adults and generally does not cause an infection in those with healthy skin. However, as pointed out in the study, 75% to 100% of atopic dermatitis patients have staph bacteria on their lesional skin and 30% to 100% of atopic dermatitis patients have staph bacteria on their non-lesional skin (Breuer et al., 2002; Gong et al., 2006; Park et al., 2013). The problem with staph bacteria is that it secretes toxins and proteases that can worsen atopic dermatitis.
MarcieMom: From your study, protease V8 was of interest which showed it led to skin barrier dysfunction. Can you explain what you learnt about staphylococcus aureus’ interaction with atopic dermatitis skin/ normal skin and how does it damage skin integrity?
Dr Davidson: In our study we did not use the whole live bacteria, but concentrated instead on its harmful proteases. Using skin cells grown in the laboratory and collecting the substances made by the bacteria Staphylococcus aureus, we were able to show that the bacterial protease V8 was the most powerful product when it came to breaking down and damaging the skin barrier. Together with studies from other research groups, this suggested that one of the main ways these bacteria can damage skin is by producing V8, and that finding ways to block this damage may help to maintain and/or restore the skin integrity in atopic dermatitis.
Interview with Dr Donald J Davison, MRC Senior Research Fellow and Senior Lecturer at University of Edinburgh on his published study on skin defences against staphylococcus aureus bacteria
Natural Skin Defence
In your study, it was mentioned that human beta defensin 2 (hBD2) is a substance on our skin that have antimicrobial properties and able to protect against skin integrity damage caused by staph bacteria protease V8. It was further noted that the level of hBD2 on atopic dermatitis skin was significantly lower than normal skin, therefore atopic dermatitis skin may be more prone to infection and unable to defend itself against staph bacteria.
MarcieMom: I hope I have understood hBD2’s role correctly; can you explain more about what you have found out about hBD2, for instance, how important is its role in maintaining skin integrity, fighting infection and the effects of protease V8?
Dr Davidson: Our bodies can make quite a wide range of substances we call antimicrobial host defence peptides (HDP). The skin is one site that produces these. These HDP have a lot of different roles in protecting us from infection and disease. hBD2 is an HDP from the defensin family. hBD2 was already known to be capable of killing bacteria in the laboratory. It is less clear if it definitely does this in normal functioning on our skin. However, it has been suggested by other researchers that the failure of atopic dermatitis skin to make as much hBD2 as one would expect (for the amount of skin inflammation or damage), could be one reason that atopic dermatitis skin lesions are prone to infection. What our new MRC-funded research discovered was that hBD2 can also stop V8 from damaging laboratory-grown skin. This worked both when we instructed the skin to make extra hBD2 (using genetic modification) and when we added hBD2 in the style of a treatment. Just how important this is in a living human remains to be seen, but it has obvious potential and shows that hBD2 can protect the skin barrier as well as kill bacteria.
Skin defences against staph bacteria protease v8
Topical Application
MarcieMom: The interesting part of your study was its demonstration that application of hBD2 was found to be protective, and therefore a possible future eczema therapeutic. How does the application of hBD2 work? What are its protective effects?
Dr Davidson: At this point we don’t know how hBD2 protects this skin barrier integrity and we are currently applying for more funding so that we can start to work this out. It may act directly on the V8 to block the damaging effects of this bacterial protease, but we’ve found that it can also help to speed up repair where damage has occurred. So hBD2 may work in more than one way.
Is this something you foresee that can be easily added into a moisturizer or would it be more likely to be a non-steroidal topical prescription?
Dr Davidson: At this stage we are still in the discovery science phase of the research, so it is too early to predict how, and even whether, it will turn out to be a useful treatment. However, in the best case scenario for the outcome of our research, I would envisage adding hBD2 (or drugs made to mimic some of its functions) into prescription moisturizer-type creams or ointments.
How would the application of hBD2 be compared with the existing eczema measures such as bleach bath to kill staph bacteria?
Dr Davidson: I’m afraid it is too early to be able to make comparisons of that kind, until we have a better understanding of exactly how hBD2 functions to protect the skin barrier.
MarcieMom: Thank you Dr Davidson once again for your time and will certainly look forward to further breakthroughs and more studies done in this area.
Reference:
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Wang B, McHugh BJ, Qureshi A, Campopiano DJ, Clarke DJ, Fitzgerald JR, Dorin JR, Weller R, Davidson DJ, IL-1beta-induced protection of keratinocytes against Staphylococcus aureus-secreted proteases is mediated by human beta defensin 2, The Journal of Investigative Dermatology (2016), doi: 10.1016/j.jid.2016.08.025.
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Breuer K, S HA, Kapp A, Werfel T (2002) Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 147:55-61.
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Gong JQ, Lin L, Lin T, Hao F, Zeng FQ, Bi ZG, et al. (2006) Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial. Br J Dermatol 155:680-7.
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Park HY, Kim CR, Huh IS, Jung MY, Seo EY, Park JH, et al. (2013) Staphylococcus aureus Colonization in Acute and Chronic Skin Lesions of Patients with Atopic Dermatitis. Ann Dermatol 25:410-6.