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Directed evolution applied in the development of Psoriasis medications

Main category: Eczema / Psoriasis
Article Date: 22 March 2013-0:00 PDT current ratings for:
Directed evolution applied in the development of Psoriasis medications
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University Ben-Gurion of researchers of the Negev (BGU), in collaboration with Teva Pharmaceutical Industries Ltd., have developed a promising drug candidate to treat psoriasis. The discovery was reported in a new paper published in chemistry and biology.

Psoriasis is a chronic, non-contagious disease characterized by covered flaming silver white crusting lesions of dead skin. An autoimmune disease, psoriasis affects at least 4 million Americans. It is caused by disturbances in the natural balance between proinflammatory and signals that inhibit inflammation.


One of the main signals involved in the progression of psoriasis is the protein of the immune system interleukin 17 (IL-17). The research team has developed a method for inhibiting pro-inflammatory signals IL-17 and proved that their engineered receptors, it-17R, is very effective in the reduction of inflammatory signals IL-17 induced in mouse models. Moreover, the injection of the receiver in a model mice with acute human psoriasis eliminated symptoms, mainly to cure this disease.


“Use of directed evolution to improve the properties of IL-17 receptor, we created engineered mutants which could prove it has a viable treatment for patients with severe psoriasis who do not respond to current drugs,” explains Dr. Amir Aharoni, one of the investigators of BGU Department of Sciences of life and the National Institute of biotechnology in the Negev.


“Given that the directed evolution method can be applied to other receptors involved in autoimmune diseases and cancer, I believe that we begin just to drill the potential of this approach,” adds Aharoni.


Directedhttp://www.eczemablog.net/ evolution is an iterative process of Darwinian optimization used in protein engineering whereby the fittest variants are selected from a collection of random mutations. Improved variants are identified and isolated by screening or selection for the property of interest. This approach is particularly advantageous in cases where no knowledge of the mechanism and the structure of the protein is available.

Article adapted by Medical News Today press release original. Click on “references” tab above for the source.
Visit our eczema / psoriasis section for the latest news on this subject. Other researchers credited ‘Directed Evolution of a receptor Soluble de IL-17 human a for the Inhibition of the Formation of plaques of Psoriasis’ in a Murine model are BGU Dr. Marianna Zaretsky and Teva researchers Dr. Liora Sklair-Tavron, Dr. Joel Kaye, Revital Etzyoni.
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Eczema Blog

Doctor: Eczema medications for children could have long-term side effects – 13WMAZ


13WMAZ
Doctor: Eczema medications for children could have long-term side effects
13WMAZ
Kids can have a lot to deal with. School, sports, bullies, the list goes on. But imagine also dealing with this as well: severe eczema. Five-year-old Allison and 11-year-old Imaan may be different ages, but they have one thing in common. “I have eczema

eczema – Google News

Doctor: Eczema medications for children could have long-term side effects – WTSP 10 News


WTSP 10 News
Doctor: Eczema medications for children could have long-term side effects
WTSP 10 News
Kids can have a lot to deal with. School, sports, bullies, the list goes on. But imagine also dealing with this as well: severe eczema. Five-year-old Allison and 11-year-old Imaan may be different ages, but they have one thing in common. “I have eczema

eczema – Google News

Doctor: Eczema medications for children could have long-term side effects – WTSP 10 News


WTSP 10 News
Doctor: Eczema medications for children could have long-term side effects
WTSP 10 News
Kids can have a lot to deal with. School, sports, bullies, the list goes on. But imagine also dealing with this as well: severe eczema. Five-year-old Allison and 11-year-old Imaan may be different ages, but they have one thing in common. “I have eczema

eczema – Google News

Alternative Medications That Can Improve Ailments And Quality Of Life

During the past few years, the media has helped to make consumers aware of the dangers of prescription medications. While these drugs may offer temporary relief, they also come with risks. And, those risks may last for an extensive period of time. They can lead to life-altering addiction. At the same time, the short-term side effects should not be ignored. If you wish to alleviate your suffering without taking the risks, you will want to check out the list of alternative medications below.

Yoga

While Yoga isn’t a medication in the traditional sense, many experts agree that this form of exercise can be therapeutic in various ways. Yoga and meditation can help to put the patient’s mind at ease, while also alleviating their pain and anxiety. In fact, it is believed that yoga can aid with a variety of ailments, including painful joints, anxiety and even depression. And, yoga can help the patient burn calories and lose weight. Therefore, partaking in yoga is truly a win-win situation. Just make sure you ease into yoga slowly, because some of the poses can take years to master.

meditation_350

Palmidrol

Over the past few years, more and more consumers have decided to begin consuming supplements on a daily basis. This can be a wise choice. Supplements help to provide the patient with the nutrients that they may not obtain through their traditional diet. This is why many have added Palmidrol to their diets. This specific chemical has been used for many years and it has been known to offer relief for diabetic pain, lower back pain and Sciatica pain. Many of the supplements that contain this chemical are capable of protecting the user against many ailments.

Generally, they can help the patient combat depression, allergy problems, pain, and even eczema. Those that want to boost their immunity, while also alleviating pain, should definitely consider adding this type of supplement to their daily diet.

Homeopathic Treatments

Homeopathy is somewhat of a controversial subject. Many people believe that homeopathic treatments are nothing more than a fraud, but others swear by them. In homeopathy, it is believed that substances, which cause symptoms in a healthy individual, can actually cure those same symptoms for someone who is sick. This form of alternative medicine has been around for many years and was originally created by Samuel Hahnemann in 1796. Again, some believe that homeopathy medications are nothing more than quackery.

Nonetheless, these medications generally contain very few active ingredients. Therefore, they will be safe and they may offer relief to some patients. Experimenting with them for yourself is recommended, since each chemical can impact each patient differently.

Others

And of course, you should remember that there many more alternative medicines. Acupuncture and kinesiotherapy have both gained in popularity over the past few years. While both treatments still have a lot of critics, many people believe sincerely that they have provided them with relief. Since neither has any notable side effects, the risks are minute. Therefore, each patient should experiment, until they’re able to find the best solution for their own unique problem. This is something that is not possible with prescription medications, since almost all of them come with negative side effects.

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