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What is Pigmentation?

Pigmentation

Pigmentation refers to the unexplained darkening (hyperpigmentation) or lightening (hypopigmentation) of the skin. Causes can usually be pinpointed to UVR exposure, trauma, medication, a chemical substance, or hormonal and Vitamin A & C deficiencies. And not forgetting essential fatty acid deficiencies. Other causes trigger skin diseases such as dermatitis, eczema and psoriasis.

Normal skin contains cells called melanocytes that produce melanin, the brown skin colouring pigment of the skin, and when these melanocytes are either abnormal or abnormally distributed, it results in pigmentation ‘problems’. Although most skin conditions that cause discolouration are harmless, people need to know when there is a cause for concern

Types of Pigmentation:

Hormonal Pigmentation

Chloasma and melasma are terms used to describe pigmentation that is caused due to abnormal hormone levels in the body. These levels are influenced by pregnancy, mild ovarian or thyroid dysfunction, the contraceptive pill and some photosensitising medications.Chloasma is also referred to as the pregnancy mask and will often fade after birth.
Melasma is seen as symmetric pigmented macules extending over large areas, the cheeks, upper lip, chin and forehead and is more common in women than men. It is also more common in you darker skin types. This however does not exclude lighter skins if there is a family history of pigmentation.

Photomelanosis

This is increased pigmentation due to sun exposure and is most commonly found on the face, neck and back. It may appear patchy or as diffused darkening of the exposed skin.

What Causes Pigmentation

Eventually most of us will struggle with some kind of pigmentation problem that occurs regardless of your ethnicity or skin colour. The skin will either appear lighter (hypopigmentation) or darker (hyperpigmentation) than normal in certain areas. This occurs because the skin produces either too much or too little melanin. Melanin is produces by melanocytes and is the pigment/colour of your skin. The amount of melanin present will determine your skin colour. Melanin is triggered by an enzyme called tyrosinase, which creates the colour of our skin, eyes, and hair.

Melanin has two major forms.

Eumelanin- brown skin and hair colour,
Pheomelan- imparts a yellow to reddish hue

Melanin is also the skin’s natural ‘Sun block’ as, depending on the amount present, it protects the skin for UV rays. You could then say that melanin or in this case a ‘tan’ is the skin’s natural defense mechanism against the sun. This is why skin type IV to VI is less susceptible to sunburn. This however, does not mean that these skin types are immune to the problems associated with pigmentation. On the contrary, pigmentation is most often seen in light to medium brown skins, such as Indian and Mediterranean skins.

Aside from sun exposure and hormones, hyperpigmentation can be caused by skin damage, such as is present in scars. Once again this is usually most prevalent in those with darker skin tones.

The major cause of darkened areas of skin, brown spots or areas of discoloration is unprotected sun exposure. These brown spots were once referred to as liver spots, but really have nothing to do with the liver. They are solely caused by the damage that UV (sun) rays cause on the skin due to over exposure and not using a good SPF. They also do not form over night and most forms of pigmentation only appear later in life due to years of sun exposure.

How do you treat pigmentation

Sunscreen

This is your skin’s major defense against the sun and is the first step in treating as well as preventing pigmentation. It is very important to use a SPF of at least 15 on your skin everyday. This is due to the fact that it is not just the sun that causes pigmentation; Fluorescent lights have also been known to cause pigmentation as well as most major light forms.

It is not only important to use UVB blockers which are blockers that prevents the skin from burning. UVA rays are the rays that age, as they penetrate deeper into the skin layers causing damage in the ‘living’ layer of the skin and therefore ageing the skin prematurely. Good UVA-protecting ingredients are titanium dioxide, zinc oxide as they are physical blockers that reflect these rays off the skin.

It is also important to remember that reapplication of a lower SPF such as a 15 is more important than putting high levels of chemicals on the skin. An important thing to remember is that an SPF gives you 93% sun coverage and an SPF 30 95% but with double the chemical content.

Vitamins

There are many vitamins on the market that help with skin dicolouraration, however the most effect are Vitamin A as it is a skin normalizer and Vitamin C as is the only vitamin that actually stops the enzyme tyrosinase form triggering the formation more melanin. There are many forms of Vitamin C used in skin care preparations. Of all the different forms, L-ascorbic acid is the most effective, because it penetrates and works in the dermis (the active layer of the skin). It is also capable of controlling the inflammatory response associated with UV light. It also speeds up the healing process in the event of a sunburn

Alpha Hydroxy Acids

It is important to remember that AHA work as exfoliants on the skin and for this reason will help lighten pigmentation of used in combination with other products. The best AHA on the market that are natural and not need to be buffered like glycolic acid, are malic and lactic acid. The AHA not only exfoliate the skin, causing better penetration of product, but also have a biological, therapeutic action within the deeper layers of the skin, which increases cell renewal.

Kojic Acid

This form of acid is often used in skin care products and is a by product of fermented rice. Some studies have shown that it can be effective in the treatment of pigmentation when combined with glycolic acid ( a synthetic, potentially irritating AHA, and if used in the daytime, can actually cause pigmentation) or glycolic acid and hydroquinone. Hydroquinone however, is an extremely controversial chemical additive used in skin lightening products, which has, in many cases, caused scarring and hyperpigmentation and are therefore restricted to prescription treatment.

Azelaic Acid

This acid is a component of grains, such as wheat, rye, and barley. If used in a 20% concentration of the cream, it has been shown to have an effect on many skin conditions. It is usually recommended to be used on acneic skins, however, some studies show an effect on skin discolouration. It also does not show severe side effects such as allergic sensitization or exogenous ochronosis, which is common in most high level pigmentation preparations. Other studies however show that it is still more irritating to the skin than hydroquinone combined with glycolic acid.

Laser Treatments

There are both ablative and non-ablative lasers on the market. They have been shown to have positive effects on the reduction of pigmentation, however with many side effects. The Laser light absorbs into the skin layers and actually ‘pushes’ the pigment to the surface and then effectively ‘strips’ the top layer of the skin, taking the pigment with it. This in turn opens the skin up to many other things, such as sundamage (which in turn would increase pigmentation), bacteria and pollution.

There are new technologies on the market that are as effective as laser treatments on pigmentation with reduced side effects. One such technology is IPL (Intense Pulsed Light) treatments that is also a form of light treatment on the skin, and has the same mechanism as Laser, without the side effects on the surface layers of the skin. The IPL light work within the deeper layers of the skin, ‘pulling’ the abnormal pigment to the surface, where it will form a ‘scab’ and once the roughness has been the removed, with the pigmentation in tow, there will be lightening of the skin in the area of treatment.

Combination Treatments

It is vitally important to remember that not one treatment will be effective on pigmentation on its own. This is why most skin care therapists as well as doctors will recommend that you use different treatments in combination with one another.

Therefore it is important to remember that using a skin care product with high levels of L-ascorbic acid (vitamin C) with a SPF 15, with AHA at night and possibly going for IPL/Laser treatments is a more effect way of treating pigmentation than having only IPL/Laser treatments.

Always remember that the pigmentation did not form overnight and it would therefore not improve overnight. It is lengthy process to lighten pigmentation; however, by following the correct methods, you will have success.

http://www.ndi.co.za/?page_id=436

How Histamine Affects Skin Pigmentation

beautiful young brunette woman with vitiligo disease close up isolated on white positive smiling, model problems concept, bad tan real problem

Histamine affects skin pigmentation in a numbers of ways: my two old buddy’s melasma and vitiligo. You know those patches of dark skin on your face that are barely covered by make up, get worse when exposed to the sun, and are aggravated by pregnancy hormones? Yeah, we have histamine and mast cells to thank for those. On the flip side we have the autoimmune skin condition vitiligo, which causes white patches to develop all over. I don’t know about you, but my skin hyper-pigmentation has been a constant source of frustration, so I decided to take a closer look into both. 

MELASMA

Sadly I couldn’t find any rights-free photos of this, and I’m far too vain to share any make up free shots of myself, so I’ll just explain. Melasma looks kind of like you didn’t scrub your face right and dirt or bronzing powder got left behind.

Fun right?

A number of studies tell us that histamine is a major melasma trigger. It seems that the release of histamine by skin mast cells, as triggered by ultraviolet light, causes these brown patches on the skin.

What about the hormone link? Yes, pregnancy hormones and birth control are involved, and I’ll be covering them in upcoming posts on the subject. Make sure to sign up to my mailing list so you don’t miss them. But other than the histamine-hormone interplay, other studies have found that histamine and prostaglandins (both released by mast cells) are the primary drivers of sunburn, which is why topical antihistamine cream has become a home care mainstay.

I’ve personally always used a piece of fresh aloe vera plant. You pretty much can’t walk more than a few steps without seeing it where I grew up in Spain, so I’d just break off a piece to nurse my poor skin on the way home from the beach. In my defence we knew little about skin cancer back in those days…

An animal study in the BMC Dermatology Journal found that silymarin cream (milk thistle) effectively treated melasma. The study authors believe that the milk thistle is reversing sunlight damage generally, not just the melasma pigmentation.

Their before and after milk thistle treatment photos were so amazing that they’ve had me frantically rubbing Herb Pharm’s pure extract into my face nightly. I’m impressed so far…

VITILIGO

The Mayo Clinic website tells us that vitiligo is triggered when cells stop producing melanin, the stuff that pigments our skin, hair, and eyes. So far we know that an immune system response, exposure to stress or chemicals, and sunburn can cause it. Complications are sunburn and skin cancer, eye inflammation, hearing loss, and of course, stress.

People with vitiligo are advised to wear sun protection of at least 30SPF and to get their hearing professionally tested. Possible treatments include topical steroid creams that may help re-pigment the skin, topical vitamin D, calcineurin inhibitors (which may trigger lymphoma and skin cancer), ultraviolet light therapy (also skin cancer risk), de-pigmentation of the rest of the skin and skin grafting.

Read my post on vitamin D and histamine here.

The histamine/mast cell link

A 2013 study found that blood histamine level appears to play a significant role in a particular type of vitiligo that’s linked to de-pigmented patches with itching.

My own vitiligo finally cleared up a few years ago. It was never very visible, just a de-pigmentation around my hands that was slowly creeping upwards. I have dealt more with melasma, and still do!

Interestingly, for other types of vitiligo, histamine may be a treatment. A 2010 study found that histamine release in the body triggered by bee venom may be able to add pigment back to the skin.

A few other options worth looking into

Melanin, the skin pigment stuff, is created by melatonin. I wrote about melatonin recently and how supplementing it may help prevent mast cells from leaking histamine. Read the post here.

A study with a small sample size found that patients with non-segmental vitiligo, which is what it’s called when the patches are symmetrical, melatonin was lower than the average. They point out that melatonin is one of the links in the body’s stress defence mechanism and that it also helps modulate immune system function. They concluded that further research was needed.

The Mayo Clinic website also shares that some studies show that Gingko biloba may help return colour in people with slow spreading vitiligo and other studies that folic acid and vitamin B12 may help.

It’s finally here! Man Food – a high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards guys, women who love to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods.

The Anti-cookbook and all liquid Anti-Detox Book, don’t treat any conditions, but feature a plethora of the high nutrient antihistamine and anti-inflammatory ingredients that have been instrumental in helping me feed myself on a limited diet. The Anti-cookbook features a four page list of antihistamine and anti-inflammatory foods and comes in regular and Paleo.

The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes.

Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.

Take a peek at my other low histamine and antihistamine cookbooks for more high nutrient recipes

——REFERENCES—–

“Vitiligo Treatments and drugs.” Mayo Clinic. N.p., n.d. Web. 24 Mar. 2017.

“What is segmental & non-segmental vitiligo?” Vitiligo Cover. N.p., 23 Jan. 2017. Web. 24 Mar. 2017

Panja, Salilkumar, Biman Bhattacharya, and Siteshchandra Lahiri. “Role of histamine as a toxic mediator in the pathogenesis of vitiligo.” Indian Journal of Dermatology 58.6 (2013): 421. Web.

Brenner, Michaela, and Vincent J. Hearing. “Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents.” Drug Discovery Today: Disease Mechanisms 5.2 (2008): n. pag. Web.

Kwon, Soon-Hyo, Young-Ji Hwang, Soo-Keun Lee, and Kyoung-Chan Park. “Heterogeneous Pathology of Melasma and Its Clinical Implications.” International Journal of Molecular Sciences 17.6 (2016): 824. Web.

Kim, Nan-Hyung, and Ai-Young Lee. “Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival.” Experimental Dermatology 19.12 (2010): 1073-079. Web.

Gilchrest, Barbara A., Nicholas A. Soter, Jeffrey S. Stoff, and Martin C. Mihm. “The human sunburn reaction: Histologic and biochemical studies.” Journal of the American Academy of Dermatology 5.4 (1981): 411-22. Web.

Hernández-Barrera, R., B. Torres-Alvarez, J. P. Castanedo-Cazares, C. Oros-Ovalle, and B. Moncada. “Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma.” Clinical and Experimental Dermatology 33.3 (2008): 305-08. Web.

Altaei, Tagreed. “The treatment of melasma by silymarin cream.” BMC Dermatology 12.1 (2012): n. pag. Web.

 

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