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Novartis Psoriasis Drug Shows Promising Results
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Main Category: Eczema / Psoriasis
Also Included In: Dermatology
Article Date: 27 Sep 2012 – 10:00 PST Current ratings for:
Novartis Psoriasis Drug Shows Promising Results 
AIN457 (secukinumab) can considerably improve the symptoms of moderate-to-severe plaque psoriasis on the feet, hands and nails when taken once weekly during the first four weeks of treatment, compared to placebo therapy, Swiss pharmaceutical giant Novartis announced today.
Novartis added that the patients on secukinumab enjoyed improved quality of life by the twelfth week of therapy.
Prof. Kristian Reich, one of the study investigators said:
“These new AIN457 data are particularly welcome since they demonstrate significant improvement in the signs and symptoms of patients, even when difficult-to-treat areas are involved. Many patients with hand, foot or nail psoriasis are restricted in their daily life and work because they may not be able to walk or use their hands, http://www.eczemablog.net/negatively impacting their quality of life.”
The AIN457 (secukinumab) trial results were presented today at the European Academy of Dermatology and Venereology (EADV) 21st Congress, in Prague, Czech Republic.
According to new data on the Phase II trial, AIN457 is almost three times as effective than placebo in alleviating moderate-to-severe plague psoriasis on the hands, feet and nails during the first month of treatment (54.3% versus 19.2% on placebo). Novartis added that “patients also benefited if they received AIN457 once every four weeks, with 39.0% experiencing either “clear” or “minimal” psoriasis after 12 weeks of treatment. Another analysis found that these AIN457 treatment schedules also notably reduced the signs and symptoms of finger nail psoriasis compared to placebo.”
The most common adverse events reports were infections.
Other data include: Twenty-five times more patients on AIN457 experienced improvements in skin-related quality of life after 12 weeks of treatment compared to those on placebo (40.8% vs 1.6%)
36.2% of patients on AIN457 had considerable improvements in pain and discomfort compared to just 1.5% of those on placebo
16.3% of those on AIN457 experienced improvement in anxiety and depressive symptoms compared to 6.2% of those on placeboNovartis explained that the effects of psoriasis on health-related quality of life are similar to those reported in such diseases as type 2 diabetes, arthritis, heart attack, cancer, and depression.
John Hohneker, Head of Development for Integrated Hospital Care for the Pharmaceuticals Division of Novartis, said:
“These encouraging results show that through its novel mode of action, AIN457 may significantly increase treatment success and improve the quality of life of patients suffering from moderate-to-severe plaque psoriasis. We look forward to receiving the results of the larger-scale and longer-term Phase III studies, which are expected in 2013.”
The AIN457 pivotal human studies for the treatment of moderate-to-severe plaque psoriasis are “on track”, the company says. The trials, involving over 3,000 participants, are attracting interest among both patients and health care professionals. Novartis says it will be releasing data on the Phase III trials in 2013. Soon after, if the data is favorable, submissions to regulatory authorities will be presented.
In an online communique today, Novartis wrote:“AIN457 is a fully human monoclonal antibody inhibiting interleukin-17A (IL-17A), a key pro-inflammatory cytokine. Proof-of-concept and Phase II studies in moderate-to-severe plaque psoriasis and arthritic conditions (psoriatic arthritis, ankylosing spondylitis and rheumatoid arthritis) have suggested that AIN457 may provide a new mechanism of action for the treatment of immune-mediated diseases.Psoriasis is a scaly, dry skin disorder. Experts say it is probably caused by genetic mutations in the patient; the immune system attacks good tissue, mistaking it for a harmful pathogen. The consequence is an overproduction of skin cells.The Phase III programs for these potential indications are ongoing, and first interpretable results are expected in 2013 for moderate-to-severe plaque psoriasis and in 2014 for arthritic conditions. Phase II studies are also ongoing in other areas, including multiple sclerosis.”
Skin cells are usually replaced every 21 to 28 days. In psoriasis patients, they are replaced much more quickly; from two to six days. The sufferer develops thick and extensive plaques (skin lesions), causing scaling, itching and pain. Over one third of all plaque psoriasis patients have moderate-to-severe symptoms.
About 2% to 3% of people worldwide are affected to some degree by plaque psoriasis – at least 125 million patients. The condition generally develops in patients aged from 11 to 45 years. Even though psoriasis is not contagious, patients are commonly discriminated against and socially excluded.
Those with symptoms on their nails, feet and hands experience considerably greater physical disabilities compared to those whose psoriasis occurs on other parts of the body. Signs and symptoms over the long-term may include: Functional disabilityThe affected areas feel as if they are burningSkin sorenessJoint problemsA secondary infectionsBetween 10% and 55% of all psoriasis patients have symptoms on their feet, hands and nails. It is notoriously difficult to treat and requires systemic treatment.
Written by Christian Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
MLA
7 Apr. 2013.
Please note: If no author information is provided, the source is cited instead.
posted by Rachel Bailey on 9 Nov 2012 at 1:33 pm
I would like to know if this drug would be considered for treatment of guttate psoriasis. I have this, also nails are affected. I was pleased to read the article, there may be some hope. I’ve had psoriasis since age of 12, am now 46 and totally fed up with it.
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Eczema Blog
Natural Cures For Eczema – 3 Natural Treatments For Eczema That Get Results
Natural cures for eczema can prove to be beneficial as this skin condition can be disruptive to your daily routine especially with the irritation it causes. Certain types of foods and some kinds of detergents have been known to trigger allergic reactions in some individuals so it’s best to avoid them at all costs. The following are natural remedies that get results when it comes to treating eczema.
1. Apply moisturizers with natural herbal ingredients
Perhaps the best method to reducing symptoms such as itchiness and redness is to apply moisturizers regularly so your skin does not get dry. Be sure to get those ointments that contain herbal ingredients such as aloe vera or witch hazel as these will help to ease the irritation and reduce swelling. It is also important to immediately apply it right after a shower or bath so moisture does not escape.
2. Take an oatmeal bath with warm water
Another natural cure for eczema is by taking an oatmeal bath by taking two cups of powdered oat and depositing it in a tub full of warm water. Avoid using hot water as this can cause symptoms to flare up which can be even more distressing. Be sure to also moisturize and to clothe yourself as rapid temperatures changes from a warm room to a cold one can trigger an outbreak.
3. Consume healthy meals with fruits and vegetables
A poor diet containing processed foods can be harmful to your body and can even weaken your immune system over a long period of time. Exercising on a regular basis and eating healthy meals rich in essential vitamins and nutrients will help to control occurrences of eczema. This lifestyle change will require patience on your part but is essential to a healthier wellbeing in the long run.
An additional helpful tip is to wear only 100% cotton clothing as anything made of wool can cause irritation which may lead to scratching. Be sure to implement these above methods and to always keep your skin moisturized while consuming healthy meals on a regular basis.
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Eczema Natural Treatment – Treat Your Eczema Naturally For Improved Results
Those who have eczema, usually also have very sensitive skin. This means that the treatment used to help the eczema should be mild but effective in the form of eczema natural treatment. Now, anyone with or without eczema should be careful about what comes into contact with their skin, however eczema sufferers need to be that bit more vigilant, due to the fragile high irritation levels.
So, what comes under the bracket of eczema natural treatment? Well, anything that is organic and does not contain chemicals, it really is as simple as that.
Most eczema sufferers will have gone down the route of steroid treatment which is effective in clearing severe eczema for a very short period of time but cannot be used long-term, due to it’s dangerous side-effects and the fact that it becomes ineffectual after prolonged use.
Eczema skin is usually very dry and cracked, so it requires consistent moisturization to keep the skin from cracking and letting in allergenic substances which facilitates an out-break of eczema. The best eczema cream is organic cream which uses only natural plant oils and extracts. Just make sure to read the ingredients in case there are any fruit, vegetable or nut extracts included in the ingredients that you have an allergy to!
Your next move in the eczema natural treatment plan is to eat a healthy and well-balanced diet. Your skin requires certain nutrients to remain healthy and eczema sufferers require additional nutrients such as zinc for healing and lots of vitamin C to help the skin regenerate healthy skin cells. Foods containing zinc include seafood, beef, chicken, nuts and seeds. Foods containing vitamin C are fruits, vegetables, pulses and tubers.
Eczema also tends to break out when foods containing preservatives are eaten. Watch out for MSG (mono-sodium glutamate) and E numbers. Those are eczema sufferers’ greatest enemies and should be avoided at all times.
Finally, high levels of stress can also put a great deal of strain on the skin, especially for those with eczema. Although it may be difficult, try to stay calm and relaxed. Taking part in activities such as yoga and tai chi are excellent as they do not induce sweating (which can in turn lead to itchy skin), are great for keeping fitness levels high as well as toning muscles and are instrumental in keeping stress levels very low.
These types of fitness activities are ideal for those with eczema on many levels and have already vastly improved the quality of life for many.
These are just a few methods in making the all important start to clearing your eczema. Already, many people have eradicated their eczema permanently using a ground-breaking new, all natural guide to healing and preventing eczema. To access the guide, continue to Eczema Natural Treatment.
Having suffered from eczema for 15 years and finally found a way to prevent eczema and maintain my skin, I feel qualified to pass on my advice. Remember to consult your doctor when embarking on a new treatment.
Find More How To Treat Eczema Naturally Articles
Baby Eczema Treatment That Gives Fast Results
Child eczema is normal and also this skin disease normally causes the skin to become dry. Children are likewise sensitive to itches, which often cause the baby to scratch the skin and also aggravate the skin ailment. Scratching on the eczema affected skin might break the skin or cause even further inflammation to happen in which might lead to a fever. Allow me personally discuss with you the actual baby eczema treatment that produce results.
The origins of eczema is not identified inside the healthcare world, nevertheless it is certainly strongly considered that it is cause by things that trigger allergies and also a weak body’s immune system. Itchy rashes may show up on the baby’s cheek, arm, thighs, crotch and neck region. The most important factor is without a doubt to prevent the infant from scratching because it can aggravate the skin condition.
To reduce the child from scratching, avoid synthetic materials and wool. You could try and get garments which is made from cotton as well as silk. There are even specially produced garments in the market which is made of 100% silk that will avoid skin discomfort. You may also try putting on socks and mittens to prevent your infant from scratching at night.
One more crucial action is to get rid of allergens from your own infant. Numerous toddlers are hypersensitive to cow’s milk products and you’ll have to switch the babies over to breast-feeding. It is usually highly recommended for the mother to keep away from common allergen for example nuts, wheat and additionally milk products in their very own diet plan prior to moving to breast-feeding.
If your own infant is presently taking solid food, you should try to stay away from food items that contain wheat, nuts, milk and also other dairy products inside your infant diet program.
Shower your baby with lukewarm water rather than warm water. Eczema flares up very easily should your skin contacts very warm water. Pick out soaps which were intended for baby and attempt to steer clear of those that are scented. Other kinds of products can certainly strip off the skin of natural oil and it may cause skin discomfort.
Always keep in mind to hydrate the skin just after bathing. Always remember to steer clear of products that are scented for the reason that could have chemical compounds that will aggravate the skin.
There are actually lots of procedures needed to treat eczema and an post is not enough to deal with every thing. However, if you’re able to follow these tips within the post, you will be able to see progress in your baby skin disorder. Additionally you can do your personal research concerning all natural remedies simply because I find them more helpful than regular remedies offered by the medical doctors.
To sum it up, you can find out more information on how to cure your baby’s eczema using this natural and holistic baby eczema treatment.
There is also a great resource that you can find on natural healing in this eczema free forever review.